Chandrasekhar Sankurathri was born to Appala Narasayya Naidu Sankurathri and Ramayamma Sankurathri on 20 November 1943 at Singarayakonda, Andhra Pradesh, India. He is the youngest of eight. He attended Municipal High School at Rajahmundry, East Godavari District, Andhra University, Waltair, Memorial University of Newfoundland, Canada and University of Alberta, Canada. Chandrasekhar Sankurathri worked as a visiting scientist for the Ministry of Fisheries, in Canada and a scientific evaluator for Canada's Ministry of Health.
Chandrasekhar Sankurathri married Manjari on 13-05-1975 at Kakinada, India. Together they had a son, Srikiran, and a daughter, Sarada. Manjari, Srikiran and Sarada were killed in the Air India Flight 182 bombing on 23 June 1985 off the coast of Ireland.
Following the bombing, he resigned his job in Canada and returned to India in 1988. He established the Manjari Sankurathri Memorial Foundation in 1989 in memory of his wife, which is a registered charity in Canada. He established the Sankurathri Foundation in India in memory of his family in 1989. The Foundations' goals are to improve the quality of life of needy people in the rural and remote areas of Andhra Pradesh. Established Sarada Vidyalayam in 1992 on his daughter’s name, which is a High school to provide free education for rural poor children. Sankurathri established Srikiran Institute of Ophthalmology in 1993, named after his son.Sankurathri Foundation is working in collaboration with the Manjari Sankurathri Memorial Foundation (MSMF), established in year 1989 at Ottawa, Canada. A board of volunteers, manage and oversee the distribution of all donations for humanitarian projects in India. In 1989, the active implementation of MSMF objectives fused the onset of The Sankurathri Foundation(SF). SF is currently managed by three volunteer trustees. Dr. Chandrasekhar Sankurathri remains the president of the MSMF and Executive Trustee of the SF. The Sankurathri Foundation was registered as a non-profit organization in India with the purpose of improving the quality of life for destitute and downtrodden in the society. This is planned through education, health care and disaster relief programs. All the activities are being organized from Kakinada, in the East Godavari District of Andhra pradesh, serving a population of over five million. Chandrasekhar lives on site and supervises all internal programs and outreach campaigns. Sankurathri Foundation is implementing educational programs through Sarada Vidyalayam,health care programs through SriKiran Institute of Ophthalmology and disaster relief programs through Spandana.